Featured Project: Dose Response Approaches for Nuclear Receptor-Mediated Modes of Action

This workshop studied the biology and dose-response relationships of receptor-driven gene changes, leading to the key events, which define a mode of action (MOA) relevant to an adverse human health outcome.  The workshop aimed to relate gene changes to phenotypical endpoints for the key events in the MOA from either a dose-response and/or a mechanisms perspective, and to determine the appropriate dose response assessment techniques based on both an understanding of the MOA and the response of nuclear receptors. The workshop was highly interactive, with participation by plenary speakers, case-study panel members, and invited experts in the various disciplines of nuclear receptor biology, toxicology, and risk assessment from industry, academia, and government.

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Featured Project: Beyond Science and Decisions: From Issue Identification to Dose-Response Assessment

SAVE THE DATE FOR NEXT MEETING! MAY 21-24 2012, AUSTIN, TX. This multi-party collaboration to continue the discussion was set forth by the National Academy of Science's Science and Decisions: Advancement of Risk Assessment (2009). Forty-five organizations came together under the aegis of the Alliance for Risk Assessment (ARA), to conduct a series of three meetings, with the ultimate goal of consensus among the participants on a methods compendium highlighting key considerations for applying dose-response techniques for common risk assessment applications. A draft of the Risk Methods Framework is now available, and is intended to serve as an evergreen database for assisting risk assessment decision-making.

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Presentations at SRA 2011